Vardegra 20 (Vardenafil 20 mg)

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Vardegra is a brand name for vardenafil, a phosphodiesterase type 5 (PDE) inhibitor used in the treatment of ED. This inhibitor stops phosphodiesterase from cramping the arteries and this aids the flow of blood through the blood vessels during sexual stimulation. Vardegra relaxes the muscles found in the walls of the blood vessels in the penis and aids the flow of blood to the organ.

When a male is aroused, signals sent from the brain causes the release of cyclic guanosine monophosphate (cGMP). It is this substance that controls the constriction and distention of blood vessels that take blood in and out of the penis causing an erection and flaccidity respectively.

Phosphodiesterase-5, another enzyme, destroys cGMP and when this happens, the blood vessels return to their normal size, hereby ending the erection. Vardenafil, which is the PDE5 inhibitor, prevents the destruction of cGMP thus prolonging erection leading to an enjoyable sexual experience.


Man takes tabletVardegra is taken 25 minutes to 1 hour prior to sexual activity, and its effect can last up to five hours.

A maximum of one tablet should be used per day i.e every 24 hours. The maximum dosage to be consumed in a day should not exceed 20 mg.

The drug will not work unless the man is sexually stimulated therefore a bit of foreplay is essential.

You can use Vardegra with or without food but it is advisable to not consume alcohol when using the drug as it slows down its action and also increases the possibility of dangerous side effects.

Vardegra is not to be used by individuals under 18 years of age.

Also, if there is a case of overdose, the patient should contact a healthcare professional immediately.


Vardegra is an effective drug in the treatment of erectile dysfunction in men, but there are a few side effects to using this medication. Some common side effects include:

runny or stuffy nose;
back pain;
stomach upset.

SweatingOn the other hand, very rare but possible side effects that may result from the use of this drug include:

ringing in one or both ears;
severe muscle pain;
irregular heartbeat;
swelling in the feet or ankles;
loss of vision;
faint feeling, or lightheadedness or shortness of breath;

If you have a painful or long-lasting erection of up to 4 hours or any of the above-listed severe negative after-effects, consult a doctor or healthcare practitioner immediately.


Below is a list of medications that shouldn’t be used in conjunction with Vardegra to prevent adverse effects.

Vardegra may react with nitrate drugs (for example, nitroglycerin). These drugs are often used in treating pains around the chest area and heart problems, so men looking to take Vardegra are advised to consult with their doctor first. Using these types of drugs alongside Vardegra can cause fainting or dizziness.

Avoid the use of vardenafil with recreational drugs containing butyl nitrate or amyl. For patients treating high blood pressure or an enlarged prostate, and are using drugs like Doxazosin and Tamsulosin, vardenafil may cause a drop in blood pressure to a minimal level. This can lead to dizziness or fainting. Your doctor may begin treatment with a lower dose of vardenafil to minimize this risk.

Anti-HIV drugsOther medications that can interact with generic Vardegra include:

macrolide antibiotics (for example, Clarithromycin, Erythromycin);
antifungals (such as Ketoconazole, Itraconazole);
HIV drugs (for example, Ritonavir, Indinavir);
hepatitis C virus protease inhibitors (such as Telaprevir, Boceprevir), Rifampin, among others.

The above-listed drugs can influence the way vardenafil is removed from the body and this can affect the functionality of the medication. Hence, they should be avoided.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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